| Datum | Wedstrijd | Uitslag |
|---|
| 30/7/2021 19:30 | Jong Zulte - Kme Machelen | - |
| 3/8/2021 19:30 | Kme Machelen - Kfc Sparta Petegem | - |
| 5/8/2021 19:30 | Kme Machelen - Ls Merendree A | - |
| 19/8/2021 19:30 | Kme Machelen - Fc Poesele A | 2 - 1 |
| 21/8/2021 17:00 | Kme Machelen - Kfc Sparta Petegem | 0 - 2 |
| 26/8/2021 19:30 | Kme Machelen - Sk Bellem | - |
| 28/8/2021 13:00 | K.vc Deerlijk Sport Reserven - Kme Machelen | - |
| 28/8/2021 15:00 | Kme Machelen - Vvsm Horebeke | - |
| 3/9/2021 20:00 | Kve Drongen A - Kme Machelen | 6 - 0 |
| 11/9/2021 15:00 | Kme Machelen - Eendr Elene-grotenberge | 2 - 0 |
| 18/9/2021 15:00 | Kvvv Ardennen - Kme Machelen | 0 - 8 |
| 2/10/2021 15:00 | Kme Machelen - Sv Sottegem | 2 - 1 |
| 16/10/2021 15:00 | Kme Machelen - Wik Eine | - |
| 23/10/2021 16:00 | Fc Poesele A - Kme Machelen | 4 - 2 |
| 30/10/2021 15:00 | Kme Machelen - Ksce Mariakerke A | 3 - 2 |
| 6/11/2021 14:30 | Zeveren Sp A - Kme Machelen | 6 - 3 |
| 13/11/2021 14:30 | Kme Machelen - Kvv St-denijs Sp A | - |
| 19/11/2021 20:00 | Tk Meldert - Kme Machelen | - |
| 27/11/2021 14:30 | Kme Machelen - Fcsm Latem A | - |
| 4/12/2021 14:30 | Ls Merendree A - Kme Machelen | - |
| 11/12/2021 14:30 | Kme Machelen - Ksc Dikkelvenne B | - |
| 18/12/2021 14:30 | Kme Machelen - Kve Drongen A | - |
| 14/1/2022 20:00 | Eendr Elene-grotenberge - Kme Machelen | - |
| 22/1/2022 15:00 | Kme Machelen - Kvvv Ardennen | - |
| 4/2/2022 20:00 | Sv Sottegem - Kme Machelen | - |
| 18/2/2022 19:30 | Wik Eine - Kme Machelen | - |
| 5/3/2022 15:00 | Kme Machelen - Fc Poesele A | - |
| 11/3/2022 20:00 | Ksce Mariakerke A - Kme Machelen | - |
| 19/3/2022 15:00 | Kme Machelen - Zeveren Sp A | - |
| 25/3/2022 20:00 | Kvv St-denijs Sp A - Kme Machelen | - |
| 2/4/2022 15:00 | Kme Machelen - Tk Meldert | - |
| 8/4/2022 20:00 | Fcsm Latem A - Kme Machelen | - |
| 23/4/2022 15:00 | Kme Machelen - Ls Merendree A | - |
| 30/4/2022 14:30 | Ksc Dikkelvenne B - Kme Machelen | - |
