| Datum | Wedstrijd | Uitslag |
|---|
| 10/7/2021 17:00 | Kme Machelen - Club Brugge Kv | - |
| 28/7/2021 19:00 | Kme Machelen - Jong Zulte | - |
| 1/8/2021 16:00 | Kme Machelen - Vc Nazareth-eke B | - |
| 5/8/2021 19:30 | Kme Machelen - Ls Merendree | - |
| 8/8/2021 16:00 | Vc Nazareth-eke B - Kme Machelen | - |
| 11/8/2021 19:45 | Kme Machelen - Ksk Zingem | - |
| 12/8/2021 19:30 | E Vinkt - Kme Machelen | - |
| 15/8/2021 16:00 | V.v. Volkegem A - Kme Machelen | 2 - 4 |
| 19/8/2021 19:30 | Kme Machelen - Fc Poesele | 1 - 4 |
| 22/8/2021 16:00 | Fce Meetjesland - Kme Machelen | - |
| 22/8/2021 16:00 | K.s.k. Grembergen - Kme Machelen | 2 - 3 |
| 26/8/2021 19:30 | Kme Machelen - Sk Bellem | - |
| 28/8/2021 17:00 | K.vc Deerlijk Sport Eerste Elftal - Kme Machelen | - |
| 4/9/2021 19:30 | Vc Nokere-kruishoutem A - Kme Machelen | 0 - 1 |
| 12/9/2021 15:00 | Kme Machelen - Kfco Burst | 1 - 4 |
| 19/9/2021 15:00 | Ksv Geraardsbergen - Kme Machelen | - |
| 26/9/2021 15:00 | Kme Machelen - Vco Meerbeke | - |
| 2/10/2021 19:30 | Kvcdt Borsbeke A - Kme Machelen | - |
| 10/10/2021 15:00 | Kme Machelen - Wik Eine | - |
| 17/10/2021 15:00 | Kfc Edeboys - Kme Machelen | - |
| 24/10/2021 15:00 | Kme Machelen - Zeveren Sp | - |
| 30/10/2021 18:00 | Kluisbergen Sp A - Kme Machelen | - |
| 7/11/2021 14:30 | Kme Machelen - Vk Nederhasselt | - |
| 14/11/2021 15:00 | Sv Sottegem A - Kme Machelen | - |
| 21/11/2021 14:30 | Kme Machelen - Vw Gijzel-oosterzele A | - |
| 28/11/2021 14:30 | Vce Houtem A - Kme Machelen | - |
| 5/12/2021 14:30 | Kme Machelen - Kssv Denderleeuw A | - |
| 12/12/2021 14:30 | Kve Winnik A - Kme Machelen | - |
| 19/12/2021 14:30 | Kme Machelen - Vc Nokere-kruishoutem A | - |
| 16/1/2022 14:30 | Kfco Burst - Kme Machelen | - |
| 23/1/2022 15:00 | Kme Machelen - Ksv Geraardsbergen | - |
| 30/1/2022 15:00 | Vco Meerbeke - Kme Machelen | - |
| 6/2/2022 15:00 | Kme Machelen - Kvcdt Borsbeke A | - |
| 13/2/2022 15:00 | Wik Eine - Kme Machelen | - |
| 20/2/2022 15:00 | Kme Machelen - Kfc Edeboys | - |
| 6/3/2022 15:00 | Zeveren Sp - Kme Machelen | - |
| 13/3/2022 15:00 | Kme Machelen - Kluisbergen Sp A | - |
| 20/3/2022 15:00 | Vk Nederhasselt - Kme Machelen | - |
| 27/3/2022 15:00 | Kme Machelen - Sv Sottegem A | - |
| 3/4/2022 15:00 | Vw Gijzel-oosterzele A - Kme Machelen | - |
| 10/4/2022 15:00 | Kme Machelen - Vce Houtem A | - |
| 24/4/2022 15:00 | Kssv Denderleeuw A - Kme Machelen | - |
| 1/5/2022 15:00 | Kme Machelen - Kve Winnik A | - |
